5-氟尿嘧啶诱发的酷似心肌梗死的心脏毒性：一例报告
5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report.
作者信息
McGlinchey P G, Webb S T, Campbell N P
机构信息
Regional Medical Cardiology Centre, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland, BT12 6BA, UK.
出版信息
BMC Cardiovasc Disord. 2001;1:3. doi: 10.1186/1471-2261-1-3. Epub 2001 Nov 22.
BACKGROUND
Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly understood.
CASE PRESENTATION
A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed. Electrocardiographs highlighting the severity of the presentation are included in the report along with coronary angiograms demonstrating the absence of significant coronary atherosclerosis.
CONCLUSION
Severe 5-fluorouracil-induced cardiotoxicity is rare, but can be severe and may mimic acute myocardial infarction, leading to diagnostic and therapeutic dilemmas. Readministration of 5-fluorouracil is not advised following an episode of cardiotoxicity.
背景
严重心脏毒性是静脉注射5-氟尿嘧啶治疗中已被记录但非常罕见的副作用。产生心脏毒性的机制尚不清楚。
病例报告
本文介绍并讨论了一例可能因冠状动脉痉挛导致的5-氟尿嘧啶诱发的心脏毒性病例，该病例酷似急性前侧壁心肌梗死。报告中包括突出显示病情严重程度的心电图，以及显示无明显冠状动脉粥样硬化的冠状动脉造影。
结论
严重的5-氟尿嘧啶诱发的心脏毒性很罕见，但可能很严重，并且可能酷似急性心肌梗死，从而导致诊断和治疗困境。发生心脏毒性事件后，不建议再次使用5-氟尿嘧啶。
Zotero 插件