Serological definition of bovine MHC class II polymorphism in Holstein-Friesians.

Analysis of the reaction patterns of 57 putative class II MHC alloantisera revealed 18 B-cell serum clusters, named Ds01-Ds18. These clusters were grouped together in such a manner that 17 provisional serological class II haplotypes were defined. Segregation in half-sib families of these class II haplotypes with serologically defined class I and 1D-IEF defined DRB3 types indicated that the 18 clusters identify class II polymorphisms in cattle and can be considered as local specificities.