• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

毒素灭活与抗原稳定：甲醛的两种不同用途。

Toxin inactivation and antigen stabilization: two different uses of formaldehyde.

作者信息

Rappuoli R

机构信息

IRIS, Immunobiological Research Institute Siena, Italy.

出版信息

Vaccine. 1994 May;12(7):579-81. doi: 10.1016/0264-410x(94)90259-3.

DOI:10.1016/0264-410x(94)90259-3
PMID:8085372
Abstract

Since the 1920s, when Ramon discovered the detoxifying properties of formaldehyde, this compound has been used to inactivate toxins, whole bacterial cells and viruses. With the development of vaccines that are detoxified by genetic manipulation, formaldehyde has a new role as a stabilizer of such genetically detoxified antigens.

摘要

自20世纪20年代拉蒙发现甲醛的解毒特性以来，这种化合物一直被用于使毒素、全细菌细胞和病毒失活。随着通过基因操作进行解毒的疫苗的发展，甲醛作为这种基因解毒抗原的稳定剂有了新的作用。

相似文献

1
Toxin inactivation and antigen stabilization: two different uses of formaldehyde.毒素灭活与抗原稳定：甲醛的两种不同用途。
Vaccine. 1994 May;12(7):579-81. doi: 10.1016/0264-410x(94)90259-3.
2
The reaction of bacterial toxins with formaldehyde and its use for antigen stabilization.细菌毒素与甲醛的反应及其在抗原稳定化中的应用。
Dev Biol Stand. 1996;87:125-34.
3
Detection of stable epitopes on formaldehyde-detoxified Pasteurella multocida toxin by monoclonal antibodies.利用单克隆抗体检测甲醛解毒多杀性巴氏杆菌毒素上的稳定表位
Vaccine. 1991 Nov;9(11):817-24. doi: 10.1016/0264-410x(91)90219-v.
4
[A study of the kinetics of detoxication of purified type A botulinum toxin by formalin].[关于福尔马林对纯化A型肉毒杆菌毒素解毒动力学的研究]
Biokhimiia. 1961 Jul-Aug;26:667-72.
5
The partial reactivation of formalin-inactivated Clostridium botulinum type C toxin.福尔马林灭活的C型肉毒梭菌毒素的部分复活
Am J Vet Res. 1961 Jul;22:770-4.
6
The effect of formaldehyde, hydrogen peroxide and genetic detoxification of pertussis toxin on epitope recognition by murine monoclonal antibodies.甲醛、过氧化氢及百日咳毒素的基因解毒对鼠单克隆抗体表位识别的影响
Vaccine. 1996 Apr;14(5):359-68. doi: 10.1016/0264-410x(95)00230-x.
7
The influence of the inactivating agent on the antigen content of inactivated Newcastle disease vaccines assessed by the in vitro potency test.通过体外效力试验评估灭活剂对新城疫灭活疫苗抗原含量的影响。
Biologicals. 2010 Jan;38(1):128-34. doi: 10.1016/j.biologicals.2009.07.006. Epub 2009 Aug 27.
8
Very fast (and safe) inactivation of foot-and-mouth disease virus and enteroviruses by a combination of binary ethyleneimine and formaldehyde.通过二乙烯亚胺和甲醛的组合实现口蹄疫病毒和肠道病毒的极快速（且安全）灭活。
Dev Biol (Basel). 2004;119:449-55.
9
[Change of electrophoretic properties of Cl. oedematiens toxin under the influence of formalin].[福尔马林影响下水肿杆菌毒素的电泳性质变化]
Biull Eksp Biol Med. 1961 Mar;51:67-71.
10
Formulation approach for the development of a stable, lyophilized formaldehyde-containing vaccine.甲醛疫苗的稳定冻干制剂的开发方法。
Eur J Pharm Biopharm. 2013 Oct;85(2):272-8. doi: 10.1016/j.ejpb.2013.04.016. Epub 2013 May 11.

引用本文的文献

1
Development of a hydrogen peroxide-inactivated vaccine that protects against viscerotropic yellow fever in a non-human primate model.一种过氧化氢灭活疫苗的研发，该疫苗在非人灵长类动物模型中可预防内脏型黄热病。
Cell Rep Med. 2024 Jul 16;5(7):101655. doi: 10.1016/j.xcrm.2024.101655.
2
Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens.化学交联的HIV-1包膜糖蛋白实验性疫苗抗原的深度结构保守性
NPJ Vaccines. 2023 Jul 13;8(1):101. doi: 10.1038/s41541-023-00696-w.
3
Increasing sensitivity of antibody-antigen interactions using photo-cross-linking.
利用光交联提高抗体-抗原相互作用的灵敏度。
Cell Rep Methods. 2023 Jun 5;3(6):100509. doi: 10.1016/j.crmeth.2023.100509. eCollection 2023 Jun 26.
4
Campylobacter vaccination reduces diarrheal disease and infant growth stunting among rhesus macaques.空肠弯曲菌疫苗接种可减少猕猴的腹泻病和婴幼儿生长迟缓。
Nat Commun. 2023 Jun 26;14(1):3806. doi: 10.1038/s41467-023-39433-1.
5
Development of a next-generation chikungunya virus vaccine based on the HydroVax platform.基于 HydroVax 平台的新一代基孔肯雅病毒疫苗的研发。
PLoS Pathog. 2022 Jul 5;18(7):e1010695. doi: 10.1371/journal.ppat.1010695. eCollection 2022 Jul.
6
Review: Vaccine Myth-Buster - Cleaning Up With Prejudices and Dangerous Misinformation.综述：疫苗迷思终结者——清除偏见和危险的错误信息。
Front Immunol. 2021 Jun 10;12:663280. doi: 10.3389/fimmu.2021.663280. eCollection 2021.
7
Assays for Determining Pertussis Toxin Activity in Acellular Pertussis Vaccines.测定无细胞百日咳疫苗中百日咳毒素活性的检测方法。
Toxins (Basel). 2019 Jul 17;11(7):417. doi: 10.3390/toxins11070417.
8
Advanced oxidation technology for the development of a next-generation inactivated West Nile virus vaccine.高级氧化技术在下一代灭活西尼罗河病毒疫苗研发中的应用。
Vaccine. 2019 Jul 9;37(30):4214-4221. doi: 10.1016/j.vaccine.2018.12.020. Epub 2018 Dec 31.
9
Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.化学稳定的 HIV-1 包膜糖蛋白的结构和免疫学相关性。
PLoS Pathog. 2018 May 10;14(5):e1006986. doi: 10.1371/journal.ppat.1006986. eCollection 2018 May.
10
Stabilized HIV-1 envelope glycoprotein trimers for vaccine use.用于疫苗的稳定化HIV-1包膜糖蛋白三聚体。
Curr Opin HIV AIDS. 2017 May;12(3):241-249. doi: 10.1097/COH.0000000000000363.