Wartofsky L, Dimond R C, Noel G L, Frantz A G, Earll J M
J Clin Endocrinol Metab. 1975 Sep;41(3):485-90. doi: 10.1210/jcem-41-3-485.
A dual isotope method allowing simultaneous analysis of both endogenous thyroidal release and peripheral thyroxine disposal was employed in four patients with thyrotoxicosis before and during propranolol therapy (160 mg/day) to determine whether beta adrenergic blockade with this agent affected the secretion or metabolism of thyroid hormone. Since catecholamines may be involved in the regulation of both thyrotropin (TSH) and prolactin (PRL) release from the pituitary, the effect of propranolol on the TSH and PRL responses to thyrotropin-releasing hormone (TRH) was also examined. In the dosage employed in these patients, propranolol had no demonstrable effect on either thyroid hormone secretion, the peripheral disposal of T4, or the TSH and prl responses to TRH.
采用一种双同位素方法，可同时分析内源性甲状腺释放和外周甲状腺素代谢情况。该方法应用于4例甲状腺毒症患者，分别在普萘洛尔治疗前（160毫克/天）和治疗期间，以确定β-肾上腺素能阻滞剂对甲状腺激素分泌或代谢是否有影响。由于儿茶酚胺可能参与垂体促甲状腺激素（TSH）和催乳素（PRL）释放的调节，因此还研究了普萘洛尔对TSH和PRL对促甲状腺激素释放激素（TRH）反应的影响。在这些患者所使用的剂量下，普萘洛尔对甲状腺激素分泌、T4的外周代谢，或TSH和PRL对TRH的反应均无明显影响。
