Costa M, Canale D, Filicori M, D'lddio S, Lenzi A
Institute of Obstetrics and Gynecology, University of Genova, Italy.
Andrologia. 1994 May-Jun;26(3):155-9.
The aim of the study described here was to evaluate any possible effect of L-carnitine on spermatozoal motility in a group of patients with unexplained asthenozoospermia in four different infertility centres. One hundred patients received 3 g d-1 of oral L-carnitine for 4 months. Sperm parameters were studied before, during and after this treatment. Motility was also studied by means of a computer-assisted sperm analysis. The results of the study indicate that L-carnitine is able to increase spermatozoal motility, both in a quantitative and in a qualitative manner (per cent motile spermatozoa increased from 26.9 +/- 1.1% to 37.7 +/- 1.1% [P < 0.001]; per cent spermatozoa with rapid linear progression increased from 10.8 +/- 0.6% to 18.0 +/- 0.9% [P < 0.001]; mean velocity increased from 28.4 +/- 0.6 microns s-1 to 32.5 +/- 0.8 microns s-1 [P < 0.001]; linearity index increased from 3.7 +/- 0.1 to 4.1 +/- 0.1 [P < 0.001], especially in the subgroup of patients with poor rapid linear progression of spermatozoa (per cent of motile spermatozoa increased from 19.3 +/- 1.9% to 40.9 +/- 1.4% [P < 0.001], and per cent of spermatozoa with rapid linear progression increased from 3.1 +/- 0.4% to 20.3 +/- 1.6% [P < 0.001]) An increase in spermatozoal output was also observed (total number of ejaculated spermatozoa increased from 142.4 +/- 10.3 10(6) to 163.3 +/- 11.0 x 10(6) [P < 0.001]). The authors conclude that oral administration of L-carnitine may improve sperm quality at least in patients with idiopathic asthenozoospermia.
本文所述研究的目的是评估左旋肉碱对四个不同不孕不育中心的一组不明原因弱精子症患者精子活力的任何可能影响。100名患者每天口服3克左旋肉碱，持续4个月。在该治疗前、治疗期间和治疗后研究精子参数。还通过计算机辅助精子分析研究精子活力。研究结果表明，左旋肉碱能够在数量和质量上提高精子活力（活动精子百分比从26.9±1.1%增加到37.7±1.1%[P<0.001]；快速直线前进的精子百分比从10.8±0.6%增加到18.0±0.9%[P<0.001]；平均速度从28.4±0.6微米/秒增加到32.5±0.8微米/秒[P<0.001]；直线性指数从3.7±0.1增加到4.1±0.1[P<0.001]），尤其是在精子快速直线前进能力差的患者亚组中（活动精子百分比从19.3±1.9%增加到40.9±1.4%[P<0.001]，快速直线前进的精子百分比从3.1±0.4%增加到20.3±1.6%[P<0.001]）。还观察到精子输出量增加（射精精子总数从142.4±10.3×10⁶增加到163.3±11.0×10⁶[P<0.001]）。作者得出结论，口服左旋肉碱至少可以改善特发性弱精子症患者的精子质量。
