Hintzen R Q, de Jong R, Lens S M, van Lier R A
Dept of Clinical (Viro-) Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Immunol Today. 1994 Jul;15(7):307-11. doi: 10.1016/0167-5699(94)90077-9.
CD27 is a lymphocyte-specific member of the tumour necrosis factor receptor (TNF-R) family, expression of which is tightly regulated during T-cell ontogeny. Recently, the ligand for CD27 was identified and was shown to be identical to CD70, a novel member of the TNF family. Functional experiments show that the interaction between CD27 and its ligand generates a co-stimulatory signal for T-cell activation. Here, Rogier Hintzen and colleagues integrate the phenotypic and functional data available on CD27 and its ligand, and propose a role for CD27 in the amplification of T-cell responses.
