5-O-去氧氨基红霉内酯A肟的芳香酯类
Aromatic esters of 5-O-desosaminylerythronolide A oxime.
作者信息
LeMahieu R A, Carson M, Kierstead R W, Pestka S
出版信息
J Med Chem. 1975 Aug;18(8):849-51. doi: 10.1021/jm00242a020.
PMID:808612
Abstract
Several substituted aromatic esters of the C-3 hydroxyl of 5-O-desosaminylerythronolide A oxime were prepared. Ribosomal binding studies showed that meta substituents on the aromatic ring gave the most active analogs. The esters described were all inactive in vivo at the maximum level tested.
摘要
制备了5-O-去氧胺基红霉内酯A肟的C-3羟基的几种取代芳基酯。核糖体结合研究表明，芳环上的间位取代基产生的类似物活性最高。所描述的酯在测试的最大剂量下在体内均无活性。
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