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鱼鳞病中的瘢痕性睑外翻:一种新的治疗方法。

Cicatricial ectropion in ichthyosis: a novel approach to treatment.

作者信息

Uthoff D, Gorney M, Teichmann C

机构信息

Eye-Hospital Kiel-Bellevue, Kiel, Germany.

出版信息

Ophthalmic Plast Reconstr Surg. 1994 Jun;10(2):92-5. doi: 10.1097/00002341-199406000-00004.

DOI:10.1097/00002341-199406000-00004
PMID:8086369
Abstract

Four kinds of ichthyosiform dermatoses have been described. Only lamellar ichthyosis or ichthyosis congenita is associated with the development of ectropion and subsequent eye symptoms. Conservative treatments have been tried but surgical correction of the ectropion was ultimately required for symptomatic relief. Autografts have been used successfully, provided an available donor site can be found. Grafts taken from the arm, eyelids, postauricular skin, and groin have been used with success. An uncircumcised youth with total body involvement from ichthyosis developed bilateral upper and lower ectropion. The penile foreskin was the only possible suitable donor site because it seemed unaffected by the disease. A circumcision was performed and the foreskin divided into four separate full-thickness skin graft triangles to treat the four-lid ectropion. There was successful resolution of the eye symptoms and a watertight closure. To our knowledge, this is a unique case in which penile foreskin has been used to correct cicatricial ectropion.

摘要

已描述了四种鱼鳞病样皮肤病。只有板层状鱼鳞病或先天性鱼鳞病与睑外翻及随后的眼部症状发展相关。已尝试过保守治疗,但最终仍需要手术矫正睑外翻以缓解症状。如果能找到可用的供区,自体移植已成功应用。取自手臂、眼睑、耳后皮肤和腹股沟的移植物已成功使用。一名患有全身鱼鳞病的未行包皮环切术的青年出现双侧上下睑外翻。阴茎包皮是唯一可能合适的供区,因为它似乎未受疾病影响。进行了包皮环切术,并将包皮分成四个单独的全厚皮肤移植三角形,以治疗四眼睑睑外翻。眼部症状成功缓解,伤口严密闭合。据我们所知,这是一例使用阴茎包皮矫正瘢痕性睑外翻的独特病例。

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Current Strategies for the Gene Therapy of Autosomal Recessive Congenital Ichthyosis and Other Types of Inherited Ichthyosis.常染色体隐性遗传性先天性鱼鳞病及其他类型遗传性鱼鳞病的基因治疗策略。
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Combined medical and surgical management for cicatricial ectropion in lamellar ichthyosis: A report of three cases.
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Long term follow up of mucous membrane grafting for cicatricial ectropion in Ichthyosis: A case report.鱼鳞病患者瘢痕性睑外翻黏膜移植的长期随访:一例报告
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