Holstege F C, van der Vliet P C, Timmers H T
Laboratory for Physiological Chemistry, Utrecht University, The Netherlands.
Biochim Biophys Acta. 1994 Sep 13;1219(1):157-9. doi: 10.1016/0167-4781(94)90260-7.
Polymerase chain reaction (PCR) of a TATA-binding protein cDNA that contains CAG triplet repeats results in heterogeneous products. This is caused by a variable loss in the number of CAG triplets. Sequence analysis of PCR products suggests that instability increases with repeat length.
对含有CAG三联体重复序列的TATA结合蛋白cDNA进行聚合酶链反应(PCR)会产生异质产物。这是由CAG三联体数量的可变丢失引起的。PCR产物的序列分析表明,不稳定性随着重复长度的增加而增加。