编码人螺旋-环-螺旋Id-1蛋白的cDNA的核苷酸序列：Id蛋白共有的功能保守残基的鉴定
Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins.
作者信息
Deed R W, Jasiok M, Norton J D
机构信息
CRC Department of Gene Regulation, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
出版信息
Biochim Biophys Acta. 1994 Sep 13;1219(1):160-2. doi: 10.1016/0167-4781(94)90261-5.
PMID:8086456
Abstract
We have determined the cDNA sequence encoding a 154 amino acid human Id-1 helix-loop-helix protein. Comparison with the amino acid sequences of human and mouse Id-2 and Id-3 proteins, reveals conservation/divergence of several residues in the helix-loop-helix domain known to be important for heterodimerisation, together with a common casein kinase II phosphorylation site.
摘要
我们已经确定了编码一种含154个氨基酸的人Id-1螺旋-环-螺旋蛋白的cDNA序列。将其与人和小鼠的Id-2及Id-3蛋白的氨基酸序列进行比较，结果显示，在已知对异源二聚化很重要的螺旋-环-螺旋结构域中，有几个残基具有保守性/差异性，同时还存在一个常见的酪蛋白激酶II磷酸化位点。
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