Fest T, de Wazières B, Lamy B, Maskani M, Vuitton D, Dupond J L
Service de Médecine Interne et d'Immunologie Clinique, CHU Jean Minjoz, Besançon, France.
Ann Hematol. 1994 Sep;69(3):147-9. doi: 10.1007/BF01695696.
We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concentrations ranging between 8.5 and 10 g/dl. In the literature, such rarely encountered hemolyzing warm-reacting agglutinins are described as causing severe hemolysis with a frequently fatal clinical outcome.
我们描述了重组α2b干扰素对一名患有特发性难治性IgM介导的自身免疫性溶血性贫血的女性的有益作用，该贫血由低滴度、高热幅度冷凝集素引起。反应是部分性的但持续存在，在干扰素中断2个月后，血红蛋白浓度在8.5至10 g/dl之间。在文献中，这种罕见的溶血温反应凝集素被描述为可导致严重溶血，临床结局往往是致命的。
