Jakobsson B, Berg U
Department of Pediatrics, Huddinge University Hospital, Karolinska Institute, Sweden.
Acta Paediatr. 1994 May;83(5):522-5. doi: 10.1111/j.1651-2227.1994.tb13072.x.
The purpose of this study was to investigate the effects of treatment with hydrochlorothiazide and hydrochlorothiazide and indomethacin combined on renal function in four boys, two with nephrogenic diabetes insipidus and two with partial nephrogenic diabetes insipidus using the clearances of inulin and para-aminohippuric acid under water diuresis and lithium clearance. Hydrochlorothiazide reduced urine flow and lithium clearance. These effects were further potentiated by addition of indomethacin. No consistent effects on renal plasma flow or glomerular filtration rate were found. It is concluded that treatment with hydrochlorothiazide alone and hydrochlorothiazide and indomethacin combined reduces urine flow in nephrogenic diabetes insipidus by increasing proximal tubular reabsorption of sodium.
本研究的目的是通过在水利尿和锂清除率情况下使用菊粉清除率和对氨基马尿酸清除率，来调查氢氯噻嗪以及氢氯噻嗪与吲哚美辛联合治疗对四名男孩肾功能的影响，其中两名患有肾性尿崩症，两名患有部分肾性尿崩症。氢氯噻嗪降低了尿流量和锂清除率。吲哚美辛的加入进一步增强了这些作用。未发现对肾血浆流量或肾小球滤过率有一致的影响。得出的结论是，单独使用氢氯噻嗪以及氢氯噻嗪与吲哚美辛联合治疗通过增加近端肾小管对钠的重吸收来降低肾性尿崩症患者的尿流量。
