Wilson P, Watson R, Ralston G E
Department of Clinical Psychology, Lansdowne Clinic, Glasgow.
BMJ. 1994 Sep 10;309(6955):641-4. doi: 10.1136/bmj.309.6955.641.
To assess recruitment to and work-load associated with methadone maintenance clinics in general practice; to investigate the characteristics of patients and outcomes associated with treatment.
Study of case notes.
Methadone maintenance clinics run jointly by general practitioners and drug counsellors in two practices in Glasgow.
46 injecting drug users receiving methadone maintenance during an 18 month period, 31 of whom were recruited to clinic based methadone maintenance treatment and 15 of whom were already receiving methadone maintenance treatment from the general practitioners. Mean (SD) age of patients entering treatment was 29.6 (5.5) years; 29 were male. They had been injecting opiates for a mean 9.9 (5.1) years, and most had a concurrent history of benzodiazepine misuse. Average reported daily intake of heroin was approximately 0.75 g. Participants in treatment had high levels of preexisting morbidity, and most stated that they committed crime daily.
2232 patient weeks of treatment were studied. Mean duration of treatment during the study period was 50.7 (21.1) weeks and retention in treatment at 26 weeks was 83%. No evidence of illicit opiate use was obtained at an average of 78% of patients' consultations where methadone had been prescribed in the previous week; for opiate injection the corresponding figure was 86%.
Providing methadone maintenance in general practice is feasible. Although costs are considerable, the reduction in drug use, especially of intravenous opiates, is encouraging. Attending clinics also allows this population, in which morbidity is considerable, to receive other health care.
评估全科医疗中美沙酮维持治疗诊所的招募情况及相关工作量;调查患者特征及与治疗相关的结局。
病历研究。
格拉斯哥两家诊所中由全科医生和药物顾问联合开办的美沙酮维持治疗诊所。
46名在18个月期间接受美沙酮维持治疗的注射吸毒者,其中31人被招募接受基于诊所的美沙酮维持治疗,15人已在接受全科医生的美沙酮维持治疗。开始治疗的患者平均(标准差)年龄为29.6(5.5)岁;29人为男性。他们注射阿片类药物的平均时间为9.9(5.1)年,大多数人同时有苯二氮䓬类药物滥用史。报告的海洛因日均摄入量约为0.75克。接受治疗的参与者有很高的既往发病水平,且大多数人表示他们每天都犯罪。
共研究了2232个患者治疗周。研究期间的平均治疗时长为50.7(21.1)周,26周时的治疗留存率为83%。在前一周已开具美沙酮处方的患者咨询中,平均78%未发现非法使用阿片类药物的证据;对于阿片类药物注射,相应数字为86%。
在全科医疗中提供美沙酮维持治疗是可行的。尽管成本可观,但药物使用的减少,尤其是静脉注射阿片类药物的减少,令人鼓舞。前往诊所就诊也使这一发病情况严重的人群能够获得其他医疗保健服务。