O'Brien M D
Department of Neurology, Guy's Hospital, London, UK.
Dementia. 1994 May-Aug;5(3-4):133-6. doi: 10.1159/000106710.
There are several factors that might be important in the development of dementia due to cerebrovascular disease. These include the volume of infarcted brain, the bilaterality and symmetry of lesions, the strategic location of small lesions, the number of lesions, the extent and density of white matter lesions and the coexistence of other pathologies, particularly Alzheimer's disease. No one factor is solely related to dementia and in most patients several of these factors combine to exceed the critical threshold for normal cognition. It is the extent of the disease which determines the development of dementia, rather than its etiology. Conversely, the possibility of treatment depends more on the etiology of the vascular disease than on the extent.
有几个因素可能在脑血管病所致痴呆的发生中起重要作用。这些因素包括梗死脑体积、病变的双侧性和对称性、小病变的关键部位、病变数量、白质病变的范围和密度以及其他病理情况的共存，尤其是阿尔茨海默病。没有一个因素单独与痴呆相关，在大多数患者中，这些因素中的几个共同作用超过正常认知的临界阈值。决定痴呆发生的是疾病的程度，而非其病因。相反，治疗的可能性更多地取决于血管病的病因，而非疾病程度。
