Bennett D A, Gilley D W, Lee S, Cochran E J
Rush Alzheimer's Disease Center, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Ill.
Dementia. 1994 May-Aug;5(3-4):148-52. doi: 10.1159/000106713.
Although white matter lesions (WMLs) are among the most common structural neuroimaging changes found on computed tomography and magnetic resonance imaging of older persons with dementia, their presence should not be misconstrued as proof that vascular disease is causing or contributing to the dementia. We report the results of several studies examining the neurobehavioral manifestations of persons meeting explicit operational criteria for Binswanger's disease (BD) and the clinical correlates of white matter changes in persons with autopsy-proven Alzheimer's disease (AD). The findings suggest that relative to persons with AD of comparable dementia severity, persons with BD have less profound impairments in episodic memory, more depressive symptomatology and a more variable rate of cognitive decline; among persons with AD, some WMLs are associated with incontinence and gait disturbance, but they do not appear to contribute to dementia severity.
尽管白质病变（WMLs）是在患有痴呆症的老年人的计算机断层扫描和磁共振成像中发现的最常见的结构性神经影像学变化之一，但它们的存在不应被误解为血管疾病正在导致或促成痴呆症的证据。我们报告了几项研究的结果，这些研究考察了符合宾斯旺格病（BD）明确操作标准的人的神经行为表现，以及经尸检证实患有阿尔茨海默病（AD）的人的白质变化的临床相关性。研究结果表明，与痴呆严重程度相当的AD患者相比，BD患者在情景记忆方面的损害较轻，抑郁症状较多，认知衰退率更不稳定；在AD患者中，一些白质病变与尿失禁和步态障碍有关，但它们似乎对痴呆严重程度没有影响。
