Mehnert H, Dietze G
MMW Munch Med Wochenschr. 1975 Jul 18;117(29-30):1221-8.
Oral diabetic therapy can be differentiated into sulfonamide derivatives and guanidine derivatives. The substances are different with respect to mode of action, sphere of indications and side effects. In the past 20 years, preparations of both classes of substance have been considerably improved by research work and the clinical experience gained. Among the sulfonamide derivatives are preparations which are highly effective, low dosed and have few side effects. The gastro-intestinal side effects of the biguanides have been counteracted by the development of slow-release preparations. In the range of indications for oral antidiabetics, it must be noted that more important forms of treatment are available in diet and insulin therapy. Therefore, all dietetic possiblities must be exhauseted, especially in overweight diabetics, before oral antidiabetics are prescribed.
口服糖尿病治疗药物可分为磺酰胺衍生物和胍衍生物。这些物质在作用方式、适应证范围和副作用方面有所不同。在过去20年中，通过研究工作和积累的临床经验，这两类物质的制剂都有了很大改进。在磺酰胺衍生物中，有些制剂高效、低剂量且副作用少。缓释制剂的研发抵消了双胍类药物的胃肠道副作用。在口服抗糖尿病药物的适应证范围内，必须注意饮食和胰岛素治疗有更重要的治疗形式。因此，在开口服抗糖尿病药物之前，必须穷尽所有饮食方法，尤其是对超重的糖尿病患者。
