Tatón J
Z Gesamte Inn Med. 1981 Jan 15;36(2):33-7.
In this review the actual stage of knowledge is mediated concerning the oral therapy of diabetes mellitus by biguanides. After a historical review the pharmacological data obtained by animal experiments as well as by clinical application are summarized and the effects and side-effects are derived. The problem of lactic acidosis and the controversial discussion due to the UGDP-study concerning the relation of the biguanides to the cardiovascular system are largely discussed. Concrete recommendations are given concerning the clinical practice by means of the communication of the revised indications and contraindications of the therapy with biguanides.
在本综述中，阐述了关于双胍类药物治疗糖尿病的实际知识阶段。在进行历史回顾后，总结了通过动物实验以及临床应用获得的药理学数据，并得出了其作用和副作用。重点讨论了乳酸酸中毒问题以及由于大学组糖尿病计划（UGDP）研究引发的关于双胍类药物与心血管系统关系的争议性讨论。通过传达双胍类药物治疗的修订适应症和禁忌症，给出了关于临床实践的具体建议。
