Lachaux A, Fournier V, Ponchon T, Loras I, Hermier M
Service de gastroentérologie et nutrition infantiles, hôpital Edouard-Herriot, Lyon, France.
Arch Pediatr. 1994 Jan;1(1):38-41.
A common biliopancreatic channel can be revealed by cholestatic episodes. Its early removal avoids the development of liver cirrhosis and the risk of carcinomatous change.
A 2 year 9 month-old girl had suffered from jaundice plus dark urine and pale stools for 2 months. A similar episode occurred 7 months later. Ultrasonography showed moderate dilatation of the intra and extrahepatic bile ducts that disappeared a few weeks later. A third episode of cholestasis with moderate dilation of the bile ducts occurred at the age of 3 year 11 months, complicated 2 weeks later by abdominal pain, vomiting and abdominal distension. Her serum amylase activity was 1,380 IU/l (N < 82). Ultrasonography and CT scan showed moderate dilation of the common hepatic duct. Liver biopsy showed pathological features consistent with bile obstruction. Endoscopic retrograde choledocopancreatography showed a long common channel with dilated extra and intrahepatic bile ducts, an incomplete pancreas divisum and numerous intracanalar stones. A sphincterotomy was performed and stones were extracted. The patient is well 18 months after surgery, with normal laboratory and ultrasonographic profiles.
A common biliopancreatic channel is often associated with choledocal cyst. Whether development of the cyst is preceded by intermittent dilation of the bile ducts, as in this case, remains to be determined.
胆汁淤积发作时可发现共同的胆胰管通道。早期切除可避免肝硬化的发生和癌变风险。
一名2岁9个月大的女孩出现黄疸、深色尿液和浅色粪便2个月。7个月后发生了类似发作。超声检查显示肝内和肝外胆管中度扩张,数周后消失。在3岁11个月时发生了第三次胆汁淤积发作,伴有胆管中度扩张,2周后并发腹痛、呕吐和腹胀。她的血清淀粉酶活性为1380 IU/l(正常<82)。超声检查和CT扫描显示肝总管中度扩张。肝活检显示病理特征与胆管梗阻一致。内镜逆行胰胆管造影显示有一条长的共同通道,肝内和肝外胆管扩张,胰腺分裂不全且管内有大量结石。进行了括约肌切开术并取出结石。术后18个月患者情况良好,实验室检查和超声检查结果正常。
共同的胆胰管通道常与胆总管囊肿相关。囊肿的发生是否如本例一样先有胆管间歇性扩张,仍有待确定。