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[胆管和胰管的共同通道。12例报告及讨论]

[Common channel for bile and pancreatic ducts. Presentation of 12 cases and discussion].

作者信息

Gauthier F, Brunelle F, Valayer J

出版信息

Chir Pediatr. 1986;27(3):148-52.

PMID:3533291
Abstract

Between 1978 and 1985, 11 girls and one boy underwent an elective operation for a congenital choledochal dilatation associated with an anomalous biliopancreatic junction. In 10 out of these 12 cases the children suffered several episodes of abdominal pain, and the diagnosis was missed since a jaundice appeared. The ultrasonographic examination demonstrated in all cases a dilatation of both extra- and intrahepatic bile ducts. The preoperative diagnosis was always established by the mean of a transhepatic cholangiography (8 cases) or a percutaneous cholecystography (4 cases), which showed in every case a dilated choledochus, and a common biliopancreatic channel, 15 to 35 mm long. A high amylase level was found in the bile in 10/10 cases when it was measured. A cholecystokinin test was performed in 4 cases, resulting in each case in a considerable increase of amylase and lipase levels in bile. All children were treated by excision of the dilated choledochus and gallbladder, followed by an hepaticojejunostomy with a Roux en Y loop. The follow-up is 6 months to 5 years for 9 children: 8 are cured, and on girl, who had a major dilatation of the left intrahepatic bile ducts, suffered from episodic abdominal pain and an episode od cholangitis 6 years after the operation. The role of such a common channel in the pathogeny of congenital choledochal cysts, acute pancreatitis in children, and biliary carcinomas in young adults is discussed according to the literatures of the last 10 years.

摘要

1978年至1985年间,11名女孩和1名男孩因先天性胆总管扩张合并胆胰管连接异常接受了择期手术。在这12例病例中,有10例儿童曾多次出现腹痛,且因出现黄疸而漏诊。超声检查在所有病例中均显示肝内外胆管扩张。术前诊断总是通过经肝胆管造影(8例)或经皮胆囊造影(4例)来确立,这些检查在每例中均显示胆总管扩张以及一条长15至35毫米的共同胆胰管。在10/10的病例中检测胆汁时发现淀粉酶水平升高。对4例进行了胆囊收缩素试验,结果每例胆汁中的淀粉酶和脂肪酶水平均显著升高。所有儿童均接受了扩张胆总管和胆囊切除术,随后进行了带Roux-en-Y袢的肝空肠吻合术。9名儿童的随访时间为6个月至5年:8例治愈,1名女孩左肝内胆管严重扩张术后6年仍有间歇性腹痛和胆管炎发作。根据过去10年的文献,讨论了这种共同通道在先天性胆总管囊肿、儿童急性胰腺炎和年轻成人胆管癌发病机制中的作用。

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