Ruíz Barrera E, Martínez-Cario Cueto S
Departamento de inmunología clínica y alergia, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México.
Rev Alerg Mex. 1994 Jan-Feb;41(1):19-24.
Eight patients (7 female, 1 male) diagnosed as being allergic to insulin, between the ages of 49 and 68, were evaluated. In seven patients there was a previous history of allergies to other drugs: 4 to penicillin, two to sulfurs and one to nalidixic acid. The clinical manifestations were predominantly systemic: ras, six patients; angioedema, 3 patients; hypotension, three patients; bronchial spasm, 2 patients; generalized eruption, one patient. All 8 patients were subjected to skin tests which were positive, one patient showed a positive local skin reaction and the other seven proved to be positive. All reactions were favorable in all cases which allowed for the continuation of the administration of insulin without adverse reactions.
对8例被诊断为对胰岛素过敏的患者（7例女性，1例男性）进行了评估，年龄在49至68岁之间。7例患者既往有对其他药物过敏史：4例对青霉素过敏，2例对磺胺类药物过敏，1例对萘啶酸过敏。临床表现主要为全身性：皮疹，6例患者；血管性水肿，3例患者；低血压，3例患者；支气管痉挛，2例患者；全身性皮疹，1例患者。所有8例患者均接受了皮肤试验，结果均为阳性，1例患者出现局部皮肤阳性反应，其余7例均为阳性。所有病例的反应均良好，这使得胰岛素的给药得以继续且无不良反应。
