Lazarus H M, Rowe J M, Goldstone A H
Department of Medicine, Ireland Cancer Center of the University Hospitals of Cleveland, Case Western Reserve University, OH.
J Hematother. 1993 Winter;2(4):457-66. doi: 10.1089/scd.1.1993.2.457.
High-dose therapy with bone marrow rescue is now regarded as an effective treatment for a variety of malignancies. In an attempt to circumvent the scarcity of HLA-matched donors, autologous marrow has been successfully used as the source of cells for hematopoietic reconstitution. There has been considerable controversy as to whether any malignant cells present in the graft could contribute to relapse of disease post-transplant. In this paper we review clinical results obtained by using autologous transplantation and present evidence on how ex vivo tumor purging may contribute to the outcome.
大剂量疗法联合骨髓救援目前被视为治疗多种恶性肿瘤的有效方法。为了克服人类白细胞抗原（HLA）匹配供体稀缺的问题，自体骨髓已成功用作造血重建的细胞来源。关于移植物中存在的任何恶性细胞是否会导致移植后疾病复发一直存在相当大的争议。在本文中，我们回顾了使用自体移植获得的临床结果，并提供了关于体外肿瘤净化如何影响治疗结果的证据。
