Spielvogel C
Département d'Anesthésie-Réanimation, Hôpital Saint-Antoine, Paris.
Cah Anesthesiol. 1994;42(2):219-21.
During the perioperative period, gastric emptying rate and first pass metabolism limit the use of oral morphine. The bioavailability of sublingual and buccal opioids is better as the uptake of active drug is governed by local blood flow. This way of administration requires patient cooperation. Sublingual buprenorphine is widely used; buccal morphine and oral transmucosal fentanyl deserve further evaluation, especially in children.
在围手术期，胃排空率和首过代谢限制了口服吗啡的使用。舌下和颊部阿片类药物的生物利用度更好，因为活性药物的吸收受局部血流控制。这种给药方式需要患者配合。舌下含服丁丙诺啡被广泛使用；颊部吗啡和口腔黏膜芬太尼值得进一步评估，尤其是在儿童中。
