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Yeast ts secretory mutation rgs1 is suppressed by the SEC4 gene of Saccharomyces cerevisiae.

作者信息

Gerassimenko O G

机构信息

Department of Molecular Biology, Faculty of Biology, Moscow State University, Russia.

出版信息

Curr Genet. 1994 Feb;25(2):178-9. doi: 10.1007/BF00309545.

DOI:10.1007/BF00309545
PMID:8087888
Abstract

Yeast rgs1 cells accumulate secretory vesicles in the cytoplasm and stop the secretion of proteins at the restrictive temperature. The ts mutation rgs1 may be suppressed by several different genes; the S. cerevisiae SEC4 gene, encoding the small G-protein involved in the late secretory stage, is one of them. Synthetic lethality of the double rgs1 sec4 mutant is demonstrated.

摘要

相似文献

1
Yeast ts secretory mutation rgs1 is suppressed by the SEC4 gene of Saccharomyces cerevisiae.
Curr Genet. 1994 Feb;25(2):178-9. doi: 10.1007/BF00309545.
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引用本文的文献

1
Deletion of the sec4 homolog srgA from Aspergillus fumigatus is associated with an impaired stress response, attenuated virulence and phenotypic heterogeneity.从烟曲霉中删除 sec4 同源物 srgA 与应激反应受损、毒力减弱和表型异质性有关。
PLoS One. 2013 Jun 13;8(6):e66741. doi: 10.1371/journal.pone.0066741. Print 2013.

本文引用的文献

1
Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway.酵母分泌途径中翻译后事件所需的23个互补组的鉴定。
Cell. 1980 Aug;21(1):205-15. doi: 10.1016/0092-8674(80)90128-2.
2
A ras-like protein is required for a post-Golgi event in yeast secretion.酵母分泌过程中高尔基体后事件需要一种类Ras蛋白。
Cell. 1987 May 22;49(4):527-38. doi: 10.1016/0092-8674(87)90455-7.
3
A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast.
酵母中分泌所需的一种GTP结合蛋白能迅速与分泌小泡和质膜结合。
Cell. 1988 Jun 3;53(5):753-68. doi: 10.1016/0092-8674(88)90093-1.
4
The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.人类Rab基因编码了一类与酵母中参与分泌过程的YPT1和SEC4产物相关的GTP结合蛋白家族。
J Biol Chem. 1989 Jul 25;264(21):12394-401.
5
Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces cerevisiae.Sec4蛋白对GTP的水解在囊泡运输中起重要作用，并且在酿酒酵母中受到一种GTP酶激活蛋白的刺激。
Mol Cell Biol. 1992 May;12(5):2017-28. doi: 10.1128/mcb.12.5.2017-2028.1992.