一名患有快速破坏性和骨质增生性髋关节炎的高脂血症患者对维生素A的耐受性降低。

Reduced vitamin A tolerance in a hyperlipidaemia patient with rapid destructive and hyperostotic osteoarthritis of the hip.

作者信息

Theiler R, Hanck A, Schreiber A, Von Hochstetter A R, Wagenhaeuser F J, Michel B A

机构信息

Department of Rheumatology and Pathology, University Hospital, Basel, Switzerland.

出版信息

Clin Rheumatol. 1994 Jun;13(2):293-8. doi: 10.1007/BF02249030.

DOI:10.1007/BF02249030

PMID:8088077

Abstract

A 59-year-old patient suffering from hyperlipidaemia developed a chronic vitamin A intoxication syndrome after ingestion of 30000 IE retinol/daily over a period of six years. Functional disability of the right hip was caused by radiologically documented hyperostosis of the acetabular circumference. Finally, a prosthesis had to be implanted because of rapid destructive osteoarthritis of the right hip. Implications of vitamin A for rheumatological management are discussed.

摘要

一名59岁的高脂血症患者在六年时间里每天摄入30000国际单位视黄醇后，出现了慢性维生素A中毒综合征。髋臼周围骨质增生经放射学记录证实，导致右髋关节功能障碍。最终，由于右髋关节迅速发展为破坏性骨关节炎，不得不植入假体。本文讨论了维生素A在风湿病治疗中的影响。