Orsatti G, Greenberg P D, Rolfes D B, Ishak K G, Paronetto F
Immunopathology Laboratory, Veterans Affairs Medical Center, Bronx, NY 10468.
Hum Pathol. 1994 Sep;25(9):936-9. doi: 10.1016/0046-8177(94)90015-9.
Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgen-stained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 microns 2 +/- 18.0; mean +/- standard deviation) was significantly larger than that of the surrounding noncancerous livers (33.2 +/- 4.7; P < .0001). These findings suggest that DNA content in fibrolamellar carcinoma (FLC) is not directly related to the clinical behavior and that other factors may be responsible for the better prognosis of this variant of HCC.
通过对福尔根染色组织切片进行图像分析，对12例纤维板层状肝细胞癌（FLC）进行了DNA倍性评估。所有肿瘤均显示非二倍体DNA分布（6例非整倍体和6例四倍体）；未发现二倍体模式。肿瘤的核面积（53.8平方微米±18.0；平均值±标准差）明显大于周围非癌性肝脏（33.2±4.7；P<.0001）。这些发现表明，纤维板层状癌（FLC）中的DNA含量与临床行为无直接关系，其他因素可能是导致这种肝癌变体预后较好的原因。
