Enders B, Hungerer K D, Zwisler O
Tropenmed Parasitol. 1975 Jun;26(2):252-60.
The principle of the latex agglutination technique was applied on the serodiagnosis of Chagas' disease. The latex particles coated with antigen from Trypanosoma cruzi are agglutinated by antibodies against T. cruzi in the serum of patients suffering thereof. In 11600 comparative determinations worked out mainly in a number of South American laboratories, the sensitivity of this test was compared with xenodiagnosis, CF, IFT and IHA. The latex Chagas test shows a mean coincidence of 90% with xenodiagnosis, 88% with CF, 75% with IFT, and 83% with IHA. The results indicate that the test is a useful new tool for the serodiagnosis of Chagas' disease. Also the data from CF, IFT and IHA were compared with each other. The latex Chagas test is sensitive even in the early stage of the disease. Also the specificity of the test was evaluated in other parasitic, bacterial and general diseases.
乳胶凝集技术原理被应用于恰加斯病的血清学诊断。涂有克氏锥虫抗原的乳胶颗粒会被恰加斯病患者血清中抗克氏锥虫的抗体凝集。在主要由一些南美实验室进行的11600次对比测定中，将该检测的灵敏度与异体接种诊断法、补体结合试验（CF）、间接荧光抗体试验（IFT）和间接血凝试验（IHA）进行了比较。乳胶恰加斯检测与异体接种诊断法的平均符合率为90%，与补体结合试验为88%，与间接荧光抗体试验为75%，与间接血凝试验为83%。结果表明该检测是恰加斯病血清学诊断的一种有用新工具。还对补体结合试验、间接荧光抗体试验和间接血凝试验的数据进行了相互比较。乳胶恰加斯检测即使在疾病早期也很灵敏。此外，还在其他寄生虫病、细菌病和一般疾病中评估了该检测的特异性。
