Kumar V, Arora H L, Sareen P M, Kumar H S
Department of Pathology, S.P. Medical College, Bikaner.
Indian J Pathol Microbiol. 1994 Jan;37(1):59-63.
Direct immunofluorescent studies of skin biopsies from 16 pemphigus vulgaris patients revealed immunoglobulin deposits in 12 (75%) cases with fluorescence at intercellular areas in epidermis. In 2 patients (12.5%) dermoepidermal junction also showed immunoglobulin deposits. IgG was the commonest type of immunoglobulin demonstrated in 12 out of 16 (75%) cases followed by IgM in 5 (31.25%) and IgA in 1 (6.25%) cases. Seven (43.75%) cases showed presence of IgG alone while IgM with IgG was found in 4 (25%) cases. One (6.25%) case showed deposition of IgG, IgM and IgA. The results indicated that demonstration of immunoglobulin in skin biopsies by direct immunofluorescent technique is quite a useful adjunct in diagnostic confirmation of pemphigus.
对16例寻常型天疱疮患者的皮肤活检组织进行直接免疫荧光研究发现，12例（75%）在表皮细胞间区域有荧光显示免疫球蛋白沉积。2例（12.5%）患者的真皮表皮交界处也显示有免疫球蛋白沉积。IgG是最常见的免疫球蛋白类型，16例中有12例（75%）显示为IgG，其次是5例（31.25%）为IgM，1例（6.25%）为IgA。7例（43.75%）仅显示有IgG，4例（25%）发现IgM与IgG同时存在。1例（6.25%）显示有IgG、IgM和IgA沉积。结果表明，通过直接免疫荧光技术在皮肤活检组织中显示免疫球蛋白，在寻常型天疱疮的诊断确认中是一项非常有用的辅助手段。
