Schwarze E W, Schwalbe P, Klein U E
Virchows Arch A Pathol Anat Histol. 1975 Jul 17;367(2):137-48. doi: 10.1007/BF00430951.
Chronic myeloid leukemia without the Philadelphia chromosome (Ph1-CML) is described and distinguished from chronic myeloid leukemia with the Philadelphia chromosome (Ph1+CML) on the basis of clinical and autopsy findings of four cases. Ph1-CML showed clinical, hematological, and patho-anatomical features which could be regarded as typical. Patho-anatomically Ph1-CML differed from Ph1+CML in the variable maturation of the leukemic proliferation in the bone marrow and extramedullary infiltrates. Up to the terminal phase Ph1-CML can be of an extremely mature cell type. However, it can also show myeloblastic transformation after an initially mature cell stage. Ph1-CML infiltrates are found in tissues and organs which Ph1+CML usually does not infiltrate or only to a low degree until a blastic crisis. On the basis of its course and clinical and patho-anatomical features Ph1-CML looks like an atypical chronic myeloid leukemia. However, it is better called an acute myeloid leukemia of the mature cell type.
根据4例慢性髓性白血病无费城染色体（Ph1 - CML）患者的临床及尸检结果，对其进行了描述，并与慢性髓性白血病有费城染色体（Ph1 + CML）进行了区分。Ph1 - CML表现出可被视为典型的临床、血液学及病理解剖学特征。病理解剖学上，Ph1 - CML与Ph1 + CML的不同之处在于骨髓中白血病增殖的成熟程度不同以及髓外浸润情况。直至终末期，Ph1 - CML可为极成熟的细胞类型。然而，它也可在最初的成熟细胞阶段后出现髓母细胞转化。Ph1 - CML浸润可见于Ph1 + CML通常不浸润或直至急变期才仅有低度浸润的组织和器官。基于其病程以及临床和病理解剖学特征，Ph1 - CML看似非典型慢性髓性白血病。然而，它更宜被称为成熟细胞型急性髓性白血病。
