Sato-Matsumura K C, Koizumi H, Matsumura T, Takahashi T, Adachi K, Ohkawara A
Department of Dermatology, Hokkaido University, Japan.
J Dermatol. 1994 Jul;21(7):501-7. doi: 10.1111/j.1346-8138.1994.tb01783.x.
A 17-year-old Japanese woman developed a lupus erythematosus-like syndrome during treatment for Graves' disease with thiamazole and propylthiouracil. Erythema, arthralgia, and low grade fever developed during therapy with thiamazole; purplish-red erythema developed during therapy with propylthiouracil. Antinuclear antibodies, anti-single-stranded DNA antibodies, and anti-double-stranded DNA antibodies were positive throughout the administration of these two drugs. Eruptions and other symptoms improved after their discontinuation. The titers of autoantibodies also decreased two months after withdrawal. The patient had HLA DR4.
一名17岁日本女性在使用甲巯咪唑和丙硫氧嘧啶治疗格雷夫斯病期间出现了类似红斑狼疮的综合征。在使用甲巯咪唑治疗期间出现了红斑、关节痛和低热；在使用丙硫氧嘧啶治疗期间出现了紫红色红斑。在使用这两种药物的整个过程中，抗核抗体、抗单链DNA抗体和抗双链DNA抗体均呈阳性。停药后皮疹和其他症状有所改善。停药两个月后自身抗体滴度也有所下降。该患者具有HLA DR4。
