Fortini A, Cappelletti C, Cecchi L, Laureano R
Centro per lo Studio dell'Ipertensione Arteriosa, Medicina Interna I, Ospedale Nuovo San Giovanni di Dio, Firenze, Italy.
J Hum Hypertens. 1994 Jun;8(6):469-74.
This study evaluated the effects of medium-term once daily administration of fosinopril (20 mg) on BP profile and on BP response to exercise in patients with mild to moderate hypertension. Twenty patients (14 males and 6 females; 25-57 years of age), after a six week drug wash-out phase, underwent 24h ambulatory BP monitoring (ABPM) (Spacelabs 90207) and, the day after, maximal bicycle exercise testing. Patients then received a once daily treatment with fosinopril and ABPM and exercise testing were repeated 45-60 days later. Fosinopril decreased average 24h SBP and DBP (-13.5 mmHg and -9.7 mmHg, respectively, P < 0.002); a significant BP reduction was observed both in day and in nighttime, without alteration in diurnal BP profile. The antihypertensive effect was still evident 24h after dosing. Trough to peak ratio was 0.58 +/- 0.16. Fosinopril induced a reduction of SBP and DBP during exercise testing (-20 and -11 mmHg at baseline; -17 and -8 mmHg at peak exercise; -24 and -14 mmHg at the sixth minute of recovery; P < 0.002), with a slight prolongation of exercise time (+46 seconds, P = 0.041). These results indicate that fosinopril at a once daily dose of 20 mg provides a sustained 24h BP reduction associated with BP reduction during physical exercise. These effects have been obtained without altering diurnal BP profile, without excessive hypotension at the time of maximal antihypertensive effect and with a slight improvement of exercise tolerance.
本研究评估了福辛普利（20毫克）每日一次中期给药对轻度至中度高血压患者血压曲线及运动时血压反应的影响。20例患者（14例男性和6例女性；年龄25 - 57岁），在经过六周的药物洗脱期后，接受24小时动态血压监测（ABPM）（Spacelabs 90207），并于次日进行最大运动负荷的自行车运动试验。之后患者接受福辛普利每日一次治疗，45 - 60天后重复进行ABPM和运动试验。福辛普利使24小时平均收缩压和舒张压分别降低（-13.5毫米汞柱和-9.7毫米汞柱，P < 0.002）；日间和夜间血压均显著降低，昼夜血压曲线无改变。给药后24小时降压效果仍明显。谷峰比值为0.58±0.16。福辛普利在运动试验期间使收缩压和舒张压降低（基线时-20和-11毫米汞柱；运动峰值时-17和-8毫米汞柱；恢复第六分钟时-24和-14毫米汞柱；P < 0.002），运动时间略有延长（+46秒，P = 0.041）。这些结果表明，每日一次剂量为20毫克的福辛普利可使24小时血压持续降低，并伴有运动时血压降低。这些效果在未改变昼夜血压曲线、最大降压效果时无过度低血压且运动耐量略有改善的情况下获得。
