Frans G J, Brand P L, Muskiet F D
St. Elisabeth Hospitaal, afd. Kindergeneeskunde, Willemstad, Curaçao, Nederlandse Antillen.
Ned Tijdschr Geneeskd. 1994 Aug 20;138(34):1712-5.
To evaluate if routine antenatal screening for congenital syphilis (CS) was adequately implemented.
Retrospective study.
Curaçao, St. Elisabeth Hospital.
From 1987-1991 16 infants were treated for congenital syphilis in the paediatric department of the St. Elisabeth Hospital. From hospital and lab records, syphilis serology of their mothers before and during pregnancy and at delivery were indexed as well as cord blood values. The response in case of positive syphilis serology was traced.
During the evaluation period the congenital syphilis incidence was 1.1/1000 life born infants. 9 pregnant women avoided prenatal care. Despite positive syphilis serology in the 1st (1 patient) and 3rd trimester (4 patients) no action was undertaken. In 4 neonates with congenital syphilis no cord blood sample for screening was taken. On 2 occasions the cord blood RPR was false-negative. (Re)screening was not performed at delivery in 3 mothers although positive serology was found during pregnancy.
Screening for congenital syphilis was not always applied. Insufficient action was noted if positive syphilis serology was detected. Intensification of screening for congenital syphilis in Curaçao is necessary especially for mothers with poor prenatal care. The need for immediate post partum screening for mother and child is stressed.
评估先天性梅毒(CS)的常规产前筛查是否得到充分实施。
回顾性研究。
库拉索岛圣伊丽莎白医院。
1987年至1991年期间,圣伊丽莎白医院儿科有16名婴儿接受了先天性梅毒治疗。从医院和实验室记录中,索引了其母亲在怀孕前、怀孕期间及分娩时的梅毒血清学检查结果以及脐血值。追踪梅毒血清学检查呈阳性时的应对情况。
在评估期间,先天性梅毒发病率为每1000例活产婴儿中有1.1例。9名孕妇未进行产前检查。尽管在孕早期(1例患者)和孕晚期(4例患者)梅毒血清学检查呈阳性,但未采取任何措施。4例先天性梅毒新生儿未采集脐血样本进行筛查。有2次脐血快速血浆反应素环状卡片试验(RPR)结果为假阴性。3名母亲在孕期梅毒血清学检查呈阳性,但在分娩时未进行(再次)筛查。
先天性梅毒筛查并非总是得到应用。如果检测到梅毒血清学检查呈阳性,所采取的措施不足。在库拉索岛,有必要加强先天性梅毒筛查,尤其是对产前检查不足的母亲。强调了产后立即对母亲和婴儿进行筛查的必要性。