Mechanism of the mitogenic and carcinogenic action of fumonisin B1, a mycotoxin.
作者信息
Wolf G
机构信息
Department of Nutritional Sciences, University of California, Berkeley.
出版信息
Nutr Rev. 1994 Jul;52(7):246-7. doi: 10.1111/j.1753-4887.1994.tb01431.x.
Abstract
Fumonisins, mycotoxins found on corn and other grains, can act as carcinogens. Recent studies have shown that fumonisin B1 stimulates cell proliferation due to inhibition of sphinganine N-acyl-transferase, an important rate limiting enzymatic step in sphingolipid biosynthesis. Subsequent accumulation of free sphingoid bases in the cell can act as tumor promoters.
摘要
Zotero 插件