Yamamoto F, Hiroi K, Honda Y
Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
Ophthalmic Res. 1994;26(3):163-8. doi: 10.1159/000267408.
We examined the effects of the antioxidant enzymes, 10,000 U/kg of superoxide dismutase (SOD) and 50,000 U/kg of catalase (CAT) on cat electroretinograms during the reperfusion after retinal ischemia. The intravenous administrations of SOD and CAT promoted the recovery of the c-wave after 30 min of ischemia but not the b-wave. At 5 min after onset of reperfusion, SOD- and CAT-treated eyes showed 90 and 110% recovery of the c-wave amplitude respectively, against 50% recovery in the untreated eyes. These results suggested that the oxygen-derived free radicals affected the retinal pigment epithelium at the early period of reperfusion.
我们研究了抗氧化酶，即10,000 U/kg超氧化物歧化酶（SOD）和50,000 U/kg过氧化氢酶（CAT）对视网膜缺血再灌注期间猫视网膜电图的影响。静脉注射SOD和CAT可促进缺血30分钟后c波的恢复，但不能促进b波的恢复。再灌注开始5分钟时，经SOD和CAT处理的眼睛c波振幅分别恢复了90%和110%，而未处理的眼睛仅恢复了50%。这些结果表明，氧衍生的自由基在再灌注早期影响视网膜色素上皮。
