Danilewicz M, Wagrowska-Danilewicz M
Zakładu Anatomii Patologicznej AM, Lodzi.
Pol Tyg Lek. 1994;49(6-7):141-3.
The authors analysed 60 cases of IgA nephropathy diagnosed in biopsy specimens with light microscope examination, immunofluorescence, and electron microscope in 37 patients. It was found that the course of disease was rather mild in the majority of patients and did not accompany renal failure. Examination in light microscope enabled to find disseminated glomerular and mesangial lesions whereas immunofluorescence--potent, granular fluorescence of IgA in mesangium, and sometimes in the walls of vascular loops. Electron microscopic examination revealed dense deposits localized in mesangium and sometimes subendothelially. It is stressed that the diagnosis of IgA nephropathy is possible after exclusion of all pathologies producing IgA deposits in mesangium.
作者对60例经活检确诊为IgA肾病的病例进行了分析，其中37例患者接受了光镜检查、免疫荧光检查和电子显微镜检查。结果发现，大多数患者的病程较为轻微，未伴有肾衰竭。光镜检查发现弥漫性肾小球和系膜病变，而免疫荧光检查显示系膜中IgA呈强颗粒状荧光，有时在血管袢壁也有。电子显微镜检查发现致密沉积物位于系膜，有时位于内皮下。强调在排除所有导致系膜中出现IgA沉积的病变后，才有可能诊断IgA肾病。
