Beaufils H, Jouanneau C, Katlama C, Sazdovitch V, Hauw J J
INSERM U 192 Hôpital des Enfants-Malades, Paris, France.
Nephrol Dial Transplant. 1995;10(1):35-8.
Between November 1983 and December 1991, we undertook a systematic study of kidney in deceased AIDS patients using light and immunofluorescence microscopy. Among the 116 examined kidneys (from 106 men and 10 women), nine (7.75%) showed diffuse mesangial IgA deposits. By light microscopy, glomerular lesions were absent or moderate (mesangial hypertrophy or some mesangial deposits). Urinary abnormalities were mild in all cases. Our study shows that the association between IgA nephropathy and HIV infection is not rare, and a review of the literature disclosed 18 reported cases. Some reported immunopathogenic data support the possibility of a link between HIV infection and IgA nephropathy.
1983年11月至1991年12月期间，我们运用光学显微镜和免疫荧光显微镜对已故艾滋病患者的肾脏进行了系统研究。在检查的116个肾脏（来自106名男性和10名女性）中，9个（7.75%）显示弥漫性系膜IgA沉积。通过光学显微镜检查，肾小球病变不存在或为中度（系膜肥大或一些系膜沉积物）。所有病例的尿液异常均较轻。我们的研究表明，IgA肾病与HIV感染之间的关联并不罕见，文献回顾发现了18例报告病例。一些报告的免疫致病数据支持HIV感染与IgA肾病之间存在联系的可能性。
