Bowling S L, Bardo M T
Department of Psychology, University of Kentucky, Lexington 40506.
Pharmacol Biochem Behav. 1994 Jun;48(2):459-64. doi: 10.1016/0091-3057(94)90553-3.
This study examined the influence of environmental enrichment on the behavioral response to amphetamine. Beginning at 21 days of age, rats were raised in one of three different environmental conditions: a) an enriched condition (EC), in which animals were caged in groups and provided with novel objects daily; b) a social condition (SC), in which animals were caged in groups without any novel objects; and c) an isolated condition (IC), in which animals were caged individually without any novel objects. At 53 days of age, animals from each environmental condition were assessed for amphetamine-induced changes in locomotor activity and reward using the conditioned place preference (CPP) paradigm. Results from saline-injected control animals indicated that EC animals exhibited less vertical activity than IC animals when exposed to the CPP apparatus. When challenged with amphetamine (0.5 or 2.0 mg/kg), there were no significant differences between SC and IC animals in either locomotor behavior or CPP. However, EC animals exhibited more horizontal and vertical activity following amphetamine than both the SC and IC animals. Similarly, EC animals exhibited a greater magnitude of amphetamine-induced CPP than both the SC and IC animals.
本研究考察了环境富集对苯丙胺行为反应的影响。从21日龄开始，将大鼠饲养在三种不同环境条件之一：a）富集条件（EC），动物群居笼养且每天提供新物品；b）社交条件（SC），动物群居笼养但无任何新物品；c）隔离条件（IC），动物单独笼养且无任何新物品。在53日龄时，使用条件性位置偏爱（CPP）范式评估来自每种环境条件的动物苯丙胺诱导的运动活动变化和奖赏。注射生理盐水的对照动物的结果表明，在接触CPP装置时，EC组动物的垂直活动比IC组动物少。当用苯丙胺（0.5或2.0mg/kg）刺激时，SC组和IC组动物在运动行为或CPP方面均无显著差异。然而，与SC组和IC组动物相比，EC组动物在注射苯丙胺后表现出更多的水平和垂直活动。同样，与SC组和IC组动物相比，EC组动物表现出更大程度的苯丙胺诱导的CPP。
