Nakae H, Endo S, Inada K, Kasai T, Yoshida M
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Res Commun Chem Pathol Pharmacol. 1994 May;84(2):197-202.
To elucidate the relationship between active oxygen and interleukin 8 (IL-8) in patients with septic adult respiratory distress syndrome (ARDS), we determined the serum levels of alpha-tocopherol, which has an antioxidant action, and IL-8 in seven patients with this disease. Serum alpha-tocopherol and IL-8 levels determined at the time of diagnosis of septic ARDS were 0.97 +/- 0.36 mg/dl and 0.98 +/- 0.99 ng/ml, respectively. A significant correlation was found between serum alpha-tocopherol level and IL-8 level (r = -0.758, p = 0.0473). These findings suggest that IL-8 activates neutrophils, which produce active oxygen.
为阐明脓毒症成人呼吸窘迫综合征（ARDS）患者体内活性氧与白细胞介素8（IL-8）之间的关系，我们测定了7例该疾病患者具有抗氧化作用的血清α-生育酚水平及IL-8水平。脓毒症ARDS诊断时测定的血清α-生育酚水平和IL-8水平分别为0.97±0.36mg/dl和0.98±0.99ng/ml。血清α-生育酚水平与IL-8水平之间存在显著相关性（r = -0.758，p = 0.0473）。这些发现提示IL-8激活产生活性氧的中性粒细胞。
