Endo S, Inada K, Ceska M, Takakuwa T, Yamada Y, Nakae H, Kasai T, Yamashita H, Taki K, Yoshida M
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
J Inflamm. 1995;45(2):136-42.
We determined the plasma concentrations of interleukin 8 (IL-8), polymorphonuclear leukocyte elastase (PMNE), and endotoxin in patients with septic shock in order to investigate the role of IL-8 and PMNE in the development of septic shock, especially in septic adult respiratory distress syndrome (ARDS). The IL-8 concentration in patients with septic shock was 6.28 +/- 9.00 ng/mL (mean +/- SD, n = 29), which was significantly higher (P < 0.0001) than the concentration in septic patients without shock (0.35 +/- 0.35 ng/mL, n = 40). There was a significant correlation between the IL-8 concentration and the PMNE concentration at the onset of septic shock (r = 0.6916, P < 0.0001). The IL-8 concentration was also significantly correlated with the endotoxin concentration (r = 0.5584, P = 0.0016). There was a significant negative correlation (r = -0.8237, P < 0.0001) between the serum PMNE concentration and the oxygenation index (PaO2/FiO2) at the onset of septic shock. These results indicate that IL-8 and PMNE are produced in large quantities when septic shock occurs, and may play a role in the development of septic ARDS.
我们测定了感染性休克患者血浆中白细胞介素8（IL-8）、多形核白细胞弹性蛋白酶（PMNE）和内毒素的浓度，以研究IL-8和PMNE在感染性休克尤其是感染性成人呼吸窘迫综合征（ARDS）发生发展中的作用。感染性休克患者的IL-8浓度为6.28±9.00 ng/mL（均值±标准差，n = 29），显著高于无休克的感染患者（0.35±0.35 ng/mL，n = 40）（P < 0.0001）。感染性休克发作时IL-8浓度与PMNE浓度之间存在显著相关性（r = 0.6916，P < 0.0001）。IL-8浓度也与内毒素浓度显著相关（r = 0.5584，P = 0.0016）。感染性休克发作时血清PMNE浓度与氧合指数（PaO2/FiO2）之间存在显著负相关（r = -0.8237，P < 0.0001）。这些结果表明，感染性休克发生时IL-8和PMNE大量产生，可能在感染性ARDS的发生发展中起作用。
