Skoglund A
Department of Oral and Maxillofacial Surgery, University Hospital of Umeå, Sweden.
Scand J Dent Res. 1994 Aug;102(4):216-22. doi: 10.1111/j.1600-0722.1994.tb01183.x.
The purpose of the present investigation was to determine, in patients with oral mucosal lesions of lichenoid character, whether it is possible with epicutaneous patch tests, to detect those who will react favorably to removal of amalgam. Of 48 patients, 19 (39.6%) showed positive patch test reactions to 1% mercury ammonium chloride, and 29 (60.4%) showed negative test results. The observation period varied from 3 months to 3 yr (mean value 1.5 yr). After treatment, 94.7% of the positive group and 86.2% of the negative group showed regression of lesions. Reactions exceeding the contact zone between amalgam restorations and lesions showed positive patch test results in 21% of the cases, as compared with 47% among those with lesions restricted to the contact areas; 85.7 and 93.9%, respectively, showed regression after removal of amalgam restorations. The results of the present study indicate that removal of amalgam usually affects the lesions favorably and that epicutaneous patch tests are of little prognostic value in patients with oral mucosal lesions of lichenoid character.
本研究的目的是确定，对于具有苔藓样特征的口腔黏膜病变患者，通过皮肤斑贴试验是否能够检测出那些对去除汞合金有良好反应的患者。48例患者中，19例（39.6%）对1%氯化汞铵斑贴试验呈阳性反应，29例（60.4%）试验结果为阴性。观察期从3个月到3年不等（平均值为1.5年）。治疗后，阳性组94.7%的患者和阴性组86.2%的患者病变消退。汞合金修复体与病变之间超出接触区的反应，21%的病例斑贴试验结果为阳性，而病变局限于接触区域的病例中这一比例为47%；分别有85.7%和93.9%的患者在去除汞合金修复体后病变消退。本研究结果表明，去除汞合金通常对病变有良好影响，对于具有苔藓样特征的口腔黏膜病变患者，皮肤斑贴试验的预后价值不大。
