Lamarre Y, Joffroy A J, Dumont M, De Montigny C, Grou F, Lund J P
Can J Neurol Sci. 1975 Aug;2(3):227-33. doi: 10.1017/s0317167100020321.
For several years our interest has been in a postural Parkinson-like tremor at 4-6/sec. which can be produced in the monkey by lesions of the central nervous system. We have also studied the effects of harmaline, a drug which evokes or intensifies the Parkinson-like tremor in lesioned animals and which also induces a fine, generalized tremor at 7-12/sec. in normal animals. The results obtained so far indicate that these two types of tremor are generated by two independent central mechanisms which do not require the integrity of peripheral feedback loops. The experimental Parkinson-like tremor is generated by a thalamo-cortical mechanism while the olivo-cerebellar system is responsible for the faster "physiological" tremor. Similar tremor mechanisms may be involved in some movement disorders in man.
几年来，我们一直关注一种频率为4 - 6次/秒的姿势性帕金森样震颤，这种震颤可通过中枢神经系统损伤在猴子身上诱发。我们还研究了harmaline的作用，这种药物能在受损动物身上引发或加剧帕金森样震颤，并且在正常动物身上也会诱发一种频率为7 - 12次/秒的细微、全身性震颤。目前得到的结果表明，这两种类型的震颤是由两种独立的中枢机制产生的，它们不需要外周反馈回路的完整性。实验性帕金森样震颤是由丘脑 - 皮质机制产生的，而橄榄小脑系统则负责更快的“生理性”震颤。类似的震颤机制可能也参与了人类的一些运动障碍。
