4-甲氧基甲苯对大鼠的四周毒性研究。

Four-week toxicity study of 4-methoxytoluene in rats.

作者信息

Brunsborg B, Meyer O, Würtzen G, Olsen P

机构信息

Institute of Toxicology, National Food Agency, Soeborg, Denmark.

出版信息

Toxicol Lett. 1994 Sep;73(3):209-12. doi: 10.1016/0378-4274(94)90060-4.

DOI:10.1016/0378-4274(94)90060-4

PMID:8091429

Abstract

4-Methoxytoluene was given by gavage to 4 groups of 20 rats at dosage levels of 0, 40, 120 or 240 mg kg-1 body weight/day for 4 weeks. There was a statistically significant decrease in serum creatinine and urea in the intermediate and high dose group for both sexes. Among males, a statistically significant decrease in the packed cell volume was observed in the high and intermediate dose group. A no-observed-effect level of 40 mg kg-1 body weight/day was determined.

摘要

将4-甲氧基甲苯以0、40、120或240毫克/千克体重/天的剂量水平经口灌胃给予4组，每组20只大鼠，持续4周。在中、高剂量组中，两性的血清肌酐和尿素均有统计学显著下降。在雄性大鼠中，高剂量组和中剂量组的红细胞压积有统计学显著下降。确定无观察到影响水平为40毫克/千克体重/天。