Holland J P, Sydserff S G, Taylor W A, Bell B A
Division of Clinical Neuroscience, St George's Hospital Medical School, Atkinson Morley's Hospital, Wimbledon, London, UK.
Stroke. 1994 Oct;25(10):2055-8; discussion 2058-9. doi: 10.1161/01.str.25.10.2055.
Calcitonin gene-related peptide is an endogenous vasodilating neuropeptide with a dense concentration in the trigeminocerebrovascular system. It is hypothesized that depletion of this peptide contributes to delayed cerebral ischemia after subarachnoid hemorrhage and that an exogenous supply of calcitonin gene-related peptide will augment ischemic cerebral blood flow and reduce neuronal injury.
In this study we have investigated the effect of an intravenous infusion of calcitonin gene-related peptide (100 ng/kg per minute), started 1 hour before and continued throughout 4 hours of focal cerebral ischemia, on cerebral blood flow and the volume of brain injury in a rat model of middle cerebral artery occlusion.
Calcitonin gene-related peptide produces a significant improvement in ischemic cerebral blood flow (32 +/- 2 compared with 13 +/- 2 mL/100 g per minute in the controls; t = 6.92, P < .0001) with a concomitant reduction in the volume of ischemic brain injury (102 +/- 22 compared with 234 +/- 19 mm3; t = 4.47, P < .001).
These findings lend support for the potential use of this peptide in the prophylactic treatment of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.
降钙素基因相关肽是一种内源性血管舒张神经肽，在三叉神经脑血管系统中浓度很高。据推测，这种肽的耗竭会导致蛛网膜下腔出血后迟发性脑缺血，而外源性补充降钙素基因相关肽将增加缺血性脑血流量并减少神经元损伤。
在本研究中，我们研究了在大鼠大脑中动脉闭塞模型中，于局灶性脑缺血前1小时开始静脉输注降钙素基因相关肽（每分钟100 ng/kg）并持续4小时，对脑血流量和脑损伤体积的影响。
降钙素基因相关肽可使缺血性脑血流量显著改善（与对照组每分钟13±2 mL/100 g相比，为32±2；t = 6.92，P <.0001），同时缺血性脑损伤体积减少（与234±19 mm³相比，为102±22；t = 4.47，P <.001）。
这些发现支持了这种肽在动脉瘤性蛛网膜下腔出血后迟发性脑缺血预防性治疗中的潜在应用。
