Grant G, Cadossi R, Steinberg G
Department of Neurosurgery, Stanford University, California 94305.
Bioelectromagnetics. 1994;15(3):205-16. doi: 10.1002/bem.2250150305.
There is evidence that electromagnetic stimulation may accelerate the healing of tissue damage following ischemia. We undertook this study to investigate the effects of low frequency pulsed electromagnetic field (PEMF) exposure on cerebral injury in a rabbit model of transient focal ischemia (2 h occlusion followed by 4 h of reperfusion). PEMF exposure (280 V, 75 Hz, IGEA Stimulator) was initiated 10 min after the onset of ischemia and continued throughout reperfusion (six exposed, six controls). Magnetic resonance imaging (MRI) and histology were used to measure the degree of ischemic injury. Exposure to pulsed electromagnetic field attenuated cortical ischemia edema on MRI at the most anterior coronal level by 65% (P < 0.001). On histologic examination, PEMF exposure reduced ischemic neuronal damage in this same cortical area by 69% (P < 0.01) and by 43% (P < 0.05) in the striatum. Preliminary data suggest that exposure to a PEMF of short duration may have implications for the treatment of acute stroke.
有证据表明，电磁刺激可能会加速缺血后组织损伤的愈合。我们进行了这项研究，以调查低频脉冲电磁场（PEMF）暴露对短暂性局灶性缺血兔模型（闭塞2小时，再灌注4小时）脑损伤的影响。缺血开始10分钟后开始进行PEMF暴露（280 V，75 Hz，IGEA刺激器），并在整个再灌注过程中持续（6只暴露组，6只对照组）。使用磁共振成像（MRI）和组织学来测量缺血损伤的程度。暴露于脉冲电磁场使最前冠状层面的MRI上皮质缺血性水肿减轻了65%（P < 0.001）。组织学检查显示，PEMF暴露使同一皮质区域的缺血性神经元损伤减少了69%（P < 0.01），纹状体中减少了43%（P < 0.05）。初步数据表明，短时间暴露于PEMF可能对急性中风的治疗有意义。
