Daniels G L, Petty A C, Reid M, Moulds M, Devenish A, Halil O
Medical Research Council Blood Group Unit, London, UK.
Transfusion. 1994 Sep;34(9):818-20. doi: 10.1046/j.1537-2995.1994.34994378285.x.
The Kell blood group system comprises 21 antigens residing on a red cell membrane glycoprotein of apparent M(r) 93,000.
Serologic techniques were used to identify a new red cell antigen. The monoclonal antibody-specific immobilization of erythrocyte antigens (MAIEA) assay was used to identify the red cell membrane component carrying that antigen.
A new high-frequency red cell antigen was identified and provisionally named RAZ. RAZ is absent from K.o red cells and from red cells treated with 2-amino-ethylisothiouronium bromide and is expressed weakly on McLeod phenotype cells. It differs from all other Kell system antigens, and no depression of other Kell system antigens on RAZ+ red cells was noticed. The RAZ antigen was shown by the MAIEA assay to be located on the Kell glycoprotein.
RAZ is a new high-frequency antigen located on the Kell glycoprotein. The MAIEA assay is a very effective method of demonstrating the membrane structure carrying a red cell antigen.
凯尔血型系统由位于一种表观分子量为93,000的红细胞膜糖蛋白上的21种抗原组成。
采用血清学技术鉴定一种新的红细胞抗原。运用红细胞抗原单克隆抗体特异性固定试验（MAIEA）鉴定携带该抗原的红细胞膜成分。
鉴定出一种新的高频红细胞抗原，并临时命名为RAZ。K.o红细胞以及经2-氨基乙基异硫脲溴化物处理的红细胞均无RAZ，且RAZ在麦克劳德表型细胞上表达较弱。它与所有其他凯尔系统抗原不同，且未观察到RAZ阳性红细胞上其他凯尔系统抗原的减弱。MAIEA试验表明RAZ抗原位于凯尔糖蛋白上。
RAZ是一种位于凯尔糖蛋白上的新的高频抗原。MAIEA试验是证明携带红细胞抗原的膜结构的一种非常有效的方法。
