Min K T, Shin Y S, Kim J R, Choi M Y, Hong J Y
Department of Anesthesiology, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 1994 Jun;35(2):218-22. doi: 10.3349/ymj.1994.35.2.218.
Plasma inorganic fluoride concentrations were measured in adult patients without hepatic or renal disease following sevoflurane-N2O anesthesia (n = 7) or enflurane-N2O anesthesia (n = 6). The anesthetic dosage of sevoflurane and enflurane was 6.48 +/- 2.15 %-hours and 6.57 +/- 2.50 %-hours, respectively. The mean peak plasma inorganic fluoride concentration in the sevoflurane group was 19.5 +/- 13.4 mumol/L 1 hour after anesthesia, which decreased to preanesthetic levels 24 hours after anesthesia. In the enflurane group the values were 13.2 +/- 5.8 mumol/L at the end of anesthesia and decreased, but remained, still twice as high as the preanesthetic level 24 hours after anesthesia. The relationship of plasma inorganic fluoride concentration and anesthetic dosage was more pronounced in the sevoflurane group (r = 0.68, slope = 4.2) than in the enflurane group (r = 0.39, slope = 1.2). In conclusion, sevoflurane-N2O anesthesia results in similar subnephrotoxic levels of plasma inorganic fluoride as enflurane-N2O anesthesia, and although the fluoride concentration had a better correlation to anesthetic dosage in the sevoflurane group than in the enflurane group, its excretion was faster in the sevoflurane group than in the enflurane group.
在无肝脏或肾脏疾病的成年患者中，测量了七氟醚 - N₂O麻醉（n = 7）或安氟醚 - N₂O麻醉（n = 6）后血浆无机氟浓度。七氟醚和安氟醚的麻醉剂量分别为6.48±2.15% - 小时和6.57±2.50% - 小时。七氟醚组麻醉后1小时血浆无机氟平均峰值浓度为19.5±13.4μmol/L，麻醉后24小时降至麻醉前水平。安氟醚组麻醉结束时的值为13.2±5.8μmol/L，有所下降，但在麻醉后24小时仍为麻醉前水平的两倍。血浆无机氟浓度与麻醉剂量的关系在七氟醚组（r = 0.68，斜率 = 4.2）比安氟醚组（r = 0.39，斜率 = 1.2）更明显。总之，七氟醚 - N₂O麻醉导致的血浆无机氟水平与安氟醚 - N₂O麻醉相似，均处于亚肾毒性水平，并且尽管七氟醚组中氟浓度与麻醉剂量的相关性比安氟醚组更好，但其在七氟醚组中的排泄比安氟醚组更快。
