Boutibonnes P
C R Acad Hebd Seances Acad Sci D. 1975 Feb 24;280(8):1031-4.
Antimicrobial activity of pure preparations of seven mycotoxins, coumarin and dicoumarin, was studied against various strains of Bacillus thuringiensis (Berliner). The acquisition of resistance to Aflatoxin B1, by a new strain designated "stable variant", obtained in the presence of mycotoxin lethal dose, is very specific. However, a relation seems to exist between Aflatoxin B1 susceptibility and sensitivity to compounds which possess a double furan ring. In vitro, coumarin exhibits an inhibitory effect against antibacterial activity of Aflatoxin B1.
研究了七种霉菌毒素纯制剂、香豆素和双香豆素对苏云金芽孢杆菌(Berliner)不同菌株的抗菌活性。在霉菌毒素致死剂量存在的情况下获得的一种新菌株“稳定变体”对黄曲霉毒素B1产生抗性的情况非常特殊。然而,黄曲霉毒素B1敏感性与对具有双呋喃环的化合物的敏感性之间似乎存在关联。在体外,香豆素对黄曲霉毒素B1的抗菌活性表现出抑制作用。