Boutibonnes P
Mycopathologia. 1979 Mar 30;67(1):45-50. doi: 10.1007/BF00436240.
Antibacterial activity of pure preparations of mycotoxins, was studied against strains of Bacillus thuringiensis (Berliner). Most of fungal metabolites used provokes: 1) Growth bacterial inhibition similar to lethal effect of antibiotics 2) Enlargment of cell volume; this cell abnormality induction resembles those obtained with mitomycin C. The bioassay of fungal toxins with B. thuringiensis can be recommended as a sensitive technique to supplement chemical characterization. By using specific cell lines to such a mycotoxin and specific inactivators as coumarin for aflatoxin, or sulfhydryl compounds for penicillic acid and patulin.
研究了霉菌毒素纯制剂对苏云金芽孢杆菌(Berliner)菌株的抗菌活性。所使用的大多数真菌代谢产物会引发:1)类似于抗生素致死效应的细菌生长抑制;2)细胞体积增大;这种细胞异常诱导类似于用丝裂霉素C所获得的情况。用苏云金芽孢杆菌对真菌毒素进行生物测定可作为一种敏感技术推荐用于补充化学表征。通过使用针对此类霉菌毒素的特定细胞系以及针对黄曲霉毒素的香豆素或针对青霉酸和展青霉素的巯基化合物等特定灭活剂。