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Congenital generalized epidermolysis bullosa in a calf.

作者信息

Agerholm J S

机构信息

Department of Pathology and Epidemiology, National Veterinary Laboratory, Copenhagen V, Denmark.

出版信息

Zentralbl Veterinarmed A. 1994 Mar;41(2):139-42. doi: 10.1111/j.1439-0442.1994.tb00076.x.

DOI:10.1111/j.1439-0442.1994.tb00076.x
PMID:8091889
Abstract

Epidermolysis bullosa is reported in a newborn calf. The disorder was lethal due to the large extension and severity of the skin lesions. Histopathologically, the defect was characterized by suprabasilar clefts located in stratum spinosum. In large areas, most epidermal layers were lost exposing stratum basale or even dermis. The basal membrane seemed normal. The disorder shared features with previous reported cases of both epidermolysis bullosa and familial acantholysis. The aetiology was not determined.

摘要

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3
Epidermolysis bullosa in Danish Hereford calves is caused by a deletion in LAMC2 gene.
丹麦赫里福德犊牛的大疱性表皮松解症是由LAMC2基因缺失引起的。
BMC Vet Res. 2015 Feb 7;11:23. doi: 10.1186/s12917-015-0334-8.