Riet-Correa F, Barros S S, Damé M C, Peixoto P V
Regional Diagnostic Laboratory, Faculty of Veterinary Medicine, Pelotas University, Brazil.
Vet Pathol. 1994 Jul;31(4):450-4. doi: 10.1177/030098589403100407.
A skin disease characterized by trauma-induced sloughing of haired skin, hooves, and horns is described in four calves from a herd of Murrah buffaloes (Bubalus bubalis) in Brazil. Affected calves were detected shortly after birth by the presence of lesions affecting the distal extremities, the scapular and gluteal regions, and the tip of the tail. On histologic evaluation of affected skin, the lesions were characterized by suprabasilar vesicles and acantholysis affecting the epidermis and outer root sheath of the hair follicle infundibulum. The basal cell layer was intact and appeared as a single layer of cuboidal cells attached to the dermis. Ultrastructurally, the region between the stratum basale and the lower stratum spinosum had widened intercellular spaces with loss of desmosomal attachments, which led to the suprabasilar separation. The disease appears to be inherited as an autosomal recessive trait.
在巴西一群摩拉水牛（Bubalus bubalis）的四头小牛中，描述了一种以创伤引起的有毛皮肤、蹄和角脱落为特征的皮肤病。患病小牛出生后不久，通过影响远端肢体、肩胛和臀区以及尾尖的病变被发现。对受影响皮肤进行组织学评估时，病变的特征是表皮和毛囊漏斗部外根鞘出现基底上水泡和棘层松解。基底细胞层完整，表现为附着于真皮的单层立方细胞。超微结构上，基底细胞层和棘层下部之间的区域细胞间隙增宽，桥粒连接丧失，导致基底上分离。该疾病似乎作为常染色体隐性性状遗传。
