挪威屠宰猪纤维化肾脏中的肾小球病变。光学显微镜和免疫组织化学研究。

Glomerular lesions in fibrotic kidneys of Norwegian slaughter pigs. Light microscopic and immunohistochemical studies.

作者信息

Jansen J H, Nordstoga K

机构信息

Department of Morphology, Genetics and Aquatic Biology, Norwegian College of Veterinary Medicine, Oslo.

出版信息

Zentralbl Veterinarmed A. 1994 Mar;41(2):91-101. doi: 10.1111/j.1439-0442.1994.tb00071.x.

DOI:10.1111/j.1439-0442.1994.tb00071.x

PMID:8091894

Abstract

An abattoir survey of renal lesions in Norwegian slaughter pigs demonstrated the presence of a macroscopic evident nephropathy characterised by pale, slightly enlarged and fibrotic kidneys in 143 out of 668 (21.4%) examined carcasses. At light microscopy fibrotic kidneys revealed glomerular lesions characterised by a diffuse mesangial proliferative glomerulopathy. Immunohistochemical examination demonstrated mesangial and paramesangial immune complex deposition containing IgM and C3, and to a lesser degree IgA and IgG in the glomeruli of fibrotic kidneys. Our observation of glomerular lesions caused by immune complex depositions in fibrotic pig kidneys are compared with mesangial nephropathies in man.

摘要

一项针对挪威屠宰猪肾脏病变的屠宰场调查显示，在668头被检查猪胴体中的143头（21.4%）中，存在一种肉眼可见的明显肾病，其特征为肾脏苍白、稍肿大且纤维化。在光学显微镜下，纤维化的肾脏显示出以弥漫性系膜增生性肾小球病为特征的肾小球病变。免疫组织化学检查表明，在纤维化肾脏的肾小球中，系膜和系膜旁有免疫复合物沉积，其中含有IgM和C3，还有少量的IgA和IgG。我们将纤维化猪肾脏中由免疫复合物沉积引起的肾小球病变观察结果与人的系膜肾病进行了比较。